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Cholesterol Lowering

Our cholesterol lowering Heart Health medications are used to lower high blood levels of cholesterol (hypercholesterolaemia) and triglycerides to reduce risk of atherosclerosis and cardiovascular disease.

Use the search feature to quickly find the product you are looking for, by entering either the active ingredient, e.g. atorvastatin, or the product name, e.g. Atorlip.

What is cholesterol?

Cholesterol is an insoluble fatty substance that is needed by the body for many functions, such as building cell membranes, producing certain hormones and transporting fat soluble vitamins around the body. It is made in the liver and also obtained from the diet. Cholesterol is transported in the blood along with triglycerides, which is another type of fat. Since cholesterol is not soluble in blood it is carried to and from the liver by lipoproteins. These include low density lipoproteins (LDL) known as “bad” cholesterol because they carry cholesterol from the liver and deposit excess in the arteries. High density lipoproteins (HDL) carry cholesterol back to the liver and are therefore called “good” cholesterol.

High cholesterol and atherosclerosis

If there is more cholesterol in the blood than the body needs, it becomes deposited in the artery walls where it can build up, blocking the arteries and causing hardened areas called plaques, which increases risk of heart disease. This condition is known as atherosclerosis. High cholesterol in the blood and other fats (triglycerides) is known as hypercholesterolaemia and this condition is usually due to lifestyle, including high-fat diet, obesity and lack of exercise, but it can be inherited. The ratio of total cholesterol over HDL (good cholesterol) is also an important consideration.

Cholesterol lowering medications

Cholesterol lowering medications are available to treat hypercholesterolaemia in people who have not responded to a low-fat diet and lifestyle changes alone; also for those with an inherited condition and who cannot lower cholesterol levels by lifestyle changes alone. They include:
  • Statins that block the production of cholesterol by the liver, by inhibiting the action of the enzyme HMG-CoA reductase that plays an important role in cholesterol synthesis. Statins only block cholesterol produced in the liver but have no effect on cholesterol that comes from fat in the diet. Several statins are available including, atorvastatin, simvastatin, pravastatin and rosuvastatin.

  • Cholesterol absorption inhibitors, like ezetimibe act directly on the small intestine wall to block the action of the sterol transporter in the intestine wall. This action inhibits intestinal absorption of cholesterol from the diet and reduces cholesterol stores in the liver, which helps lower blood cholesterol levels.

  • Fibrates like fenofibrate activate the enzyme Peroxisome Proliferator Activated Receptor type alpha (PPARα) that regulates the production of another enzyme involved in the breakdown of lipids in the blood. It also reduces the production of proteins that transport LDL lipids but increases the production of proteins that transport HDL. The overall effect is to lower triglycerides, total cholesterol, and LDL (bad) cholesterol, and increase HDL (good) cholesterol.

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"Please pass on my thank you to Bruce who was exceptional this morning in his assistance to me. Each employee of In-house pharmacy has provided excellence in customer service. The issues I have experienced with my bank etc have been quite frustrating but resolved thanks to the help provided by In-house. I have been a long-standing customer with In-house and I have been every provided with the very best customer service guiding me through each and every time."
Lisa SA, AUS • October 2020
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Jennifer OR, USA • October 2020
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Nancy CA, USA • October 2020
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Breanna HI, USA • March 2023
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""You all have no idea how amazing you are. You have been my angels for a few years now and I can't be more pleased with the fact that I found your company. I have only ever had one issue with your company and even that wasn't on you (it was actually my fault). Other than that it has all been smooth sailing and I am extremely grateful. I was opening a package from you all today and noticed how you have upgraded your packaging. This was the first package I received with individual items packaged in separate little baggies. I really appreciated it. Short answer: thank you all for being such a great company. I truly truly truly appreciate it!!! HOPE YOU WERE ALL DOING SOMETHING AMAZING FOR WINTER SOLSTICE AND THAT YOUR NEXT 20 YEARS ARE THE BEST YOU COULD POSSIBLY HAVE!!!.""
Mian WA, USA • February 2021
 

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