Onsior (robenacoxib) 6mg

Onsior general information

What is Onsior used for?

Onsior tablets 6mg are used for cats to treat acute (short term) pain and inflammation associated with musculoskeletal disorders (problems with the muscles and bones) and for moderate postoperative pain and inflammation associated with orthopaedic (bone) surgery, such as declawing, and other surgery including ovariohysterectomy (spayed), and castration (neutering).  Onsior tablets 6mg are only suitable for cats with a weight no less than 2.5 kg (5.5 lbs) and are no less than 4 months of age.  Onsior tablets 6mg are not effective for dogs.

How does Onsior work?

Onsior tablets 6mg contain robenacoxib, which is a nonsteroidal anti-inflammatory drug (NSAID) of the coxib class and has anti-inflammatory, analgesic and anti-pyretic action (reduces fever).  Onsior tablets 6mg work by blocking the production of specific chemicals called prostaglandins (PG) that mediate inflammation.  Robenacoxib in Onsior tablets 6mg is a highly selective and specific inhibitor of the enzyme cyclooxygenase 2 (COX-2) that is induced during the inflammation process and is responsible for the synthesis of inflammatory prostaglandins like PGE2, which causes pain, swelling and other symptoms of inflammation¹.  Robenacoxib in Onsior tablets 6mg has minimal effect on the cyclooxygenase 1 enzyme (COX-1) that is needed for normal cellular processes such as kidney and platelet function and also protects the gastrointestinal mucosa, which protects against gastrointestinal side effects¹.  Robenacoxib in Onsior tablets 6mg enters and leaves the blood rapidly to target the site of inflammation² so that it is fast acting, being effective within 30 minutes and lasts for 24hours.  By inhibiting the action of COX-2 Onsior tablets 6mg relieve the symptoms of inflammation, including pain and swelling.   

What does Onsior contain?

Onsior tablets 6mg contain the active ingredient robenacoxib, a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation in cats.

Treating pain and inflammation in cats with Onsior

Onsior tablets 6mg contain robenacoxib, which is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation in cats.  Onsior tablets 6mg help control acute pain and inflammation associated with musculoskeletal disorders (problems with the muscles and bones) and for moderate postoperative pain and inflammation associated with orthopaedic (bone) surgery, such as declawing, and other surgery including ovariohysterectomy (spayed), and castration (neutering).  Robenacoxib in Onsior tablets 6mg is a specific inhibitor of the enzyme cyclooxygenase 2 (COX-2) that is induced during the inflammation process and is responsible for the synthesis of inflammatory prostaglandins like PGE2, which causes pain, swelling and other symptoms of inflammation.  Onsior tablets 6mg are fast acting and effective within 30 minutes.

What are the side effects of Onsior?

The most commonly reported side effects when taking Onsior tablets 6mg include: decrease in appetite, vomiting, change in bowel movements such as diarrhoea or change in stool colour, change in drinking or urination.

When should Onsior not be used?

You should not give Onsior tablets 6mg to your cat if your cat:

• is allergic to robenacoxib or any ingredients in Onsior
• is less than 2.5 kg (5.5 lbs) and is no less than 4 months of age
• has a loss of appetite or decrease in appetite
• has blood in their stool or vomit
• have kidney or liver disease
• has a condition causing dehydration
• is taking medicines that interact with Onsior, including other NSADIs, aspirin, or corticosteroids.

How should Onsior be given to your cat?

You should give your cat Onsior tablets 6mg whole and by mouth, with or without food, once daily.  Onsior tablets 6mg are small and yeast flavoured to make them more palatable to cats.  The first dose should be given 30 minutes prior to surgery.  You should follow your vet’s instructions and give your cat Onsior tablets 6mg for a maximum of 3 days. 

How long should you give your cat Onsior?

You should follow your vet’s instructions and give your cat Onsior tablets 6mg for a maximum of 3 days. 

Missed dose of Onsior

If you miss a dose of Onsior give it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not give a double dose.

How should Onsior be stored?

You should store your Onsior below 25°C in a cool dry place. 

References

1. Giraudel JM, Toutain PL, King JN, Lees P.  Differential inhibition of cyclooxygenase isoenzymes in the cat by the NSAID robenacoxib.  J Vet Pharmacol Ther 2009; 32(1):31-40.
2. Pelligand L, King JN, Toutain PL, Elliott J, Lees P. Pharmacokinetic/pharmacodynamic modelling of robenacoxib in a feline tissue cage model of inflammation.  J Vet Phamacol Ther 2012; 35: 19-32.