Natclovir (Ganciclovir 250mg) 30 Capsules 250mg

Natclovir general information 

What is Natclovir used for?

Natclovir, also known as Ganciclovir, is an antiviral medication used primarily to treat infections caused by cytomegalovirus (CMV). CMV is a common virus that can cause serious complications, especially in people with weakened immune systems, such as those with HIV/AIDS or individuals who have undergone organ transplantation.

How does Natclovir work?

In short Natclovir works by inhibiting the replication of the CMV virus, thereby helping to control the infection and prevent its spread within the body. Here's how it works:

1. Inhibition of Viral DNA Synthesis: Ganciclovir is a prodrug, meaning it is inactive until it is converted into its active form inside the body. Once inside the body, Ganciclovir is converted into its active form by enzymes in virus-infected cells. This active form interferes with the synthesis of viral DNA by inhibiting the action of viral DNA polymerase, an enzyme necessary for the replication of viral DNA.

2. Incorporation into Viral DNA: Ganciclovir's active form resembles one of the building blocks of DNA. When the virus attempts to replicate its DNA, Ganciclovir's active form is incorporated into the viral DNA strand. However, Ganciclovir lacks the necessary chemical groups to allow further DNA chain elongation, effectively terminating the DNA replication process.

3. Prevention of Viral Replication: By interfering with viral DNA synthesis and terminating DNA replication, Ganciclovir prevents the virus from replicating and spreading within the body. This helps to control the viral infection and reduce its severity.

What does Natclovir contain?

Natclovir capsules contain 250mg of Ganciclovir.

What are the side effects of Natclovir?

The most common side effects of Natclovir is: Nausea, Vomiting, Diarrhea, Headache, Dizziness, Fatigue, Fever, Rash, Loss of appetite, Abdominal pain, Changes in taste, Insomnia, Muscle aches, Joint pain, Anemia (low red blood cell count), Neutropenia (low white blood cell count), Thrombocytopenia (low platelet count), Elevated liver enzymes, Kidney problems, Hair loss (alopecia)

When should Natclovir not be used?

You should not use Natclovir if you:

• Are allergic or hypersensitive to Ganciclovir or any of the inactive ingredients in Natclovir
• Are pregnant or are breastfeeding without discussing with a healthcare provider.
• Have severe kidney and/or liver impairment.
• Have bone marrow suppression.
• Have Neutropenia or thrombocytopenia
• Are receiving myelosuppressive or nephrotoxic drugs: Natclovir may interact with other medications, particularly those that are myelosuppressive (suppress bone marrow function) or nephrotoxic (toxic to the kidneys). Concurrent use of Natclovir with these drugs may increase the risk of adverse effects and require dosage adjustments.

How should Natclovir be taken?

Natclovir capsules should be swallowed whole with a full glass of water. They can be taken with or without food. It's essential to avoid crushing, chewing, or opening the capsules, as this can alter the drug's release mechanism and effectiveness.

How long should Natclovir be taken?

You should take your Natclovir tablets continually for as long as recommended by your doctor. Discontinuing treatment prematurely may increase the risk of recurrence or treatment failure.

Missed dose of Natclovir?

If you miss a dose of Natclovir take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Natclovir be stored?

Natclovir capsules should be stored at room temperature away from moisture and heat. They should be kept out of reach of children and pets.