Agoprex general information

What is Agoprex tablets 25mg used for?

Agoprex tablets 25mg are used to treat depression (a mood disorder that involves persistent feelings of sadness, being slowed down, anxiety, worthlessness and loss of interests) Furthermore Agoprex is used for major depressive disorder especially in non-responders and intolerant to SSRIs, Generalized anxiety disorder, Bipolar depression, Sleep disturbances, Seasonal affective disorder, Migraine and cluster headaches.

How does Agoprex tablets 25mg work?

The active ingredient Agomelatine is a compound that acts on melatoninergic (MT1 and MT2) and serotoninergic 5-HT2C receptors, introducing the concept of Melatonin Agonist and Selective Serotonin Antagonist (MASSA). By stimulating MT1 and MT2 receptors, it normalizes disrupted circadian rhythms and sleep-wake cycles without inhibiting serotonin, norepinephrine, or dopamine uptake like traditional antidepressants. Instead, it antagonizes the 5-HT2C receptor, which increases norepinephrine and dopamine levels in the frontal cortex, leading to antidepressant and anxiolytic effects, as well as increased slow-wave sleep. Agomelatine may also promote neurogenesis and have neuroprotective effects, enhancing its antidepressant properties. Clinical studies show rapid improvement in sleep disturbances and antidepressant effects within weeks of treatment, making it potentially effective for seasonal affective disorder, anxiety, and bipolar depression.

What does Agoprex tablets 25mg contain? 

Agoprex tablets 25mg contains the active ingredient Agomelatine 25mg, an antidepressant used to treat depression, reduce the feeling of anxiety and improve patients mood. It also contains silicified microcrystalline cellulose, mannitol, povidone, colloidal anhydrous silica, crospovidone, sodium stearyl fumarate, magnesium stearate, stearic acid, hypromellose, macrogol, titanium dioxide (E171), talc, yellow iron oxide (E172).

What are the side effects of Agoprex tablets 25mg?

The most commonly reported side effects when taking Agoprex tablets 25mg include headache, dizziness, sleepiness, nausea, diarrhoea, constipation, abdominal pain, tiredness, anxiety, abnormal dreams, increase in liver enzyme levels, weight gain, blurred vision.

When should Agoprex tablets 25mg not be used?

You should not use Agoprex tablets 25mg if you;

• Are allergic to Agomelatine or any ingredients in Agoprex
• Are pregnant or breastfeeding, without discussion with your doctor
• Have active liver problems
• Are taking medication that interacts with Agoprex such as Fluvoxamine, Propranolol, Estrogens, Rifampicin, Enoxacin or Ciprofloxacin.

How should Agoprex tablets 25mg be used?

You should take your Agoprex tablets 25mg with or without food as directed by your doctor. Your doctor may increase or decrease your dose, depending on how well you respond and any side effects.  You may not see any benefit for up to 2 weeks, but you should continue to take your Agoprex tablets 25mg for as long as recommended by your doctor.

How long should you use Agoprex tablets 25mg

You should continue to take your Agoprex tablets 25mg for as long as recommended by your doctor, which may be for 3 - 6 weeks or months, depending on your condition and your doctor’s recommendations. 

Missed dose of Agoprex tablets 25mg.

If you miss a dose of Agoprex tablets 25mg take it as soon as you remember unless it is time to take the next does, then skip the missed dose. Do not take a double dose.

How should Agoprex tablets 25mg be stored?

You should store your Agoprex tablets 25mg in a cool and dry place away from light.