Trazonil-50 (Trazodone 50mg)

Trazonil-50 general information

What is Trazonil-50 used for?

Trazonil-50 tablets 50mg are used to treat all types of depression including depression accompanied by anxiety, to relieve symptoms of depression including anxiety, loss of interest in usual activities, disturbed sleep, change in appetite, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide.  Trazonil-50 tablets are also used treat anxiety disorders that may affect daily activities and relationships with others including, obsessive compulsive disorder (OCD), social anxiety disorder (social phobia), generalised anxiety disorder and other situations that cause anxiety, such as fear of flying and agoraphobia.  Trazonil-50 is also used as a sedative to help people who suffer from sleep problems due to anxiety or agitation. 

How does Trazonil-50 work?

Trazonil-50 tablets 50mg contain trazodone, an antidepressant that is chemically unrelated to known tricyclic, tetracyclic, selective serotonin reuptake inhibitor (SSRI) or other antidepressant agents.  Although the mechanism by which Trazonil-50 tablets 50mg work as an antidepressant is not fully known, it does acts in the brain to correct the chemical imbalance of neurotransmitters (brain chemicals nerve use cells to communicate), particularly serotonin that controls many body activities, including regulating mood.  An imbalance in brain neurotransmitters like serotonin and noradrenaline, is thought to be one of the major causes of depression and other mood disorders, including anxiety.  Trazodone in Trazonil-50 tablets is thought to increase serotonin and noradrenaline levels by potentiation of these neurotransmitters, which is increasing their activity; as well as having some SSRI activity, by inhibiting the reuptake of serotonin by the nerve cells, making more serotonin available for stimulation of nerve pathways that control mood.  However, it is a much weaker SSRI than other drugs in this class.  Trazodone in Trazonil-50 also has central anti-serotonin effect, by blocking receptors for serotonin, and this action is thought to be what gives Trazonil-50 tablets 50mg their sedative and anxiety reducing properties.

What does Trazonil-50 contain?

Trazonil-50 tablets 50mg contain the active ingredient trazodone, an antidepressant drug used to treat depression and anxiety.

Treating depression with Trazonil-50

Trazonil-50 contains trazodone, an antidepressant that is used to treat all types of depression including depression accompanied by anxiety and to relieve symptoms of depression, including anxiety, loss of interest in usual activities, disturbed sleep, change in appetite, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide.  One of the major causes of depression is thought to be an imbalance of neurotransmitters (brain chemical that allows nerve cells to communicate) like serotonin and noradrenaline, which control many body activities, including regulating mood.  Trazodone in Trazonil-50 tablets 50mg is thought to increase serotonin and noradrenaline levels by potentiation of these neurotransmitters, which is increasing their activity; as well as having some activity as a selective serotonin reuptake inhibitor (SSRI), by inhibiting the reuptake of serotonin by the nerve cells, making more serotonin available for stimulation of nerve pathways that control mood.  These actions restore the balance in brain neurotransmitters, which helps relieve symptoms of depression.

Trazonil-50 for anxiety disorders

Trazonil-50 contains trazodone, an antidepressant that is used treat anxiety disorders that may affect daily activities and relationships with others, including, obsessive compulsive disorder (OCD), social anxiety disorder (social phobia), generalised anxiety disorder and other situations of anxiety, such as fear of flying and agoraphobia.  Trazonil-50 tablets 50mg are also used as a sedative to help people who suffer from sleep problems due to anxiety or agitation.  An imbalance in brain neurotransmitters like serotonin and noradrenaline, is thought to be one of the major causes of anxiety.  Trazodone in Trazonil-50 tablets 50mg is thought to increase serotonin and noradrenaline levels by potentiation of these neurotransmitters, which is increasing their activity; as well as having some activity as selective serotonin reuptake inhibitor (SSRI), by inhibiting the reuptake of serotonin by the nerve cells, making more serotonin available for stimulation of nerve pathways that control mood.  Trazodone in Trazonil-50 also has central anti-serotonin effect, by blocking receptors for serotonin and this action is thought to be what gives Trazonil-50 tablets 50mg their sedative and anxiety reducing properties.

What are the side effects of Trazonil-50?

The most commonly reported side effects when taking Trazonil-50 tablets 50mg, include, dizziness, insomnia, agitation, tiredness, dry mouth, gastrointestinal disturbances (diarrhoea, nausea, vomiting, constipation), headache, feeling weak, weight loss, tremor, low blood pressure, blurred vision, and confusion.

When should Trazonil-50 not be used?

You should not use Trazonil-50 tablets if you:

• are allergic to trazodone or any ingredients in Trazonil-50
• are pregnant or are breastfeeding
• have liver or kidney disease
• have cardiovascular disease, particularly angina or recent myocardial infarction
• have schizophrenia or other psychotic disorders as Trazonil-50 may cause worsening of psychotic symptoms
• taking any monoamine oxidase inhibitor medications as these can cause serious reactions if taken with Trazonil-50 or within 14 days
• taking other medication that interacts with Trazonil-50, including, monoamine oxidase inhibitors (MAOIs) for depression, the anticonvulsant carbamazepine, phenytoin for epilepsy, digoxin for heart failure, ritonavir for HIV, antibiotic such as ketoconazole or itraconazole

What medications interact with Trazonil-50?

Several medications interact with Trazonil-50 tablets and should either not be taken while you are taking Trazonil-50 or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction with Trazonil-50: monoamine oxidase inhibitors (MAOIs) for depression;
• Drugs that affect Trazonil-50: the anticonvulsant carbamazepine, ritonavir for HIV, antibiotic such as ketoconazole or itraconazole
• Drugs that are affected by Trazonil-50: phenytoin for epilepsy, digoxin for heart failure

How should Trazonil-50 be taken?

You should take your Trazonil-50 tablets 50mg swallowed whole with a glass of water after food once a day in the evening, or in divided doses with food.  The dose you take and how often depends of your doctor’s recommendations, and your doctor may increase your dose, depending on what you are being treated for.  You should continue to take your Trazonil-50 for several weeks or months, depending on your condition and your doctor’s recommendations. 

How long should you take Trazonil-50?

You should continue to take your Trazonil-50 regularly for several weeks or months, depending on your condition and your doctor’s recommendations. 

Missed dose of Trazonil-50

If you miss a dose of Trazonil-50 tablets 50mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Trazonil-50 be stored?

You should store your Trazonil-50 tablets 50mg below 25°C in a cool dry place.