Kenozole-B Cream (Ketoconazole & Beclomethasone)

Kenozole-B Cream general information

What is Kenozole-B Cream used for?

Kenozole-B Cream is a topical skin cream used as a topical treatment for fungal infections of the skin and scalp, where there are with inflammatory changes or a hypersensitivity reaction.  Kenozole-B Cream is effective against tinea, a dermatophyte fungus also known as ringworm that causes fungal infection in different parts of the body including, ringworm of the foot, also known as Athlete's foot (tinea pedis), the body (tinea corporis), the groin (tinea cruris or jock itch), and the scalp (tinea capitis).  Kenozole-B Cream 2% is also used to treat infection by the yeast fungus Malassezia, which causes Pityriasis versicolor, characterised by flaky discoloured patches that appear on the chest and back; also seborrhoeic dermatitis, a form of dermatitis or inflammation of the skin that affects mainly the scalp and face.  Kenozole-B Cream 2% is also effective against infection with  the yeast fungus Candida, which causes cutaneous candidiasis, characterised by itchy red rash on various parts of the body, usually in warm, moist creased areas of skin, like under the arms and in the groin.  Kenozole-B Cream helps relieve symptoms of fungal infection with inflammation, such as itching, redness, swelling, dryness, crusting, scaling and discomfort.

How does Kenozole-B Cream work?

Kenozole-B Cream contains the topical corticosteroid beclomethasone, which is a medium potency anti-inflammatory that is more potent than hydrocortisone and has anti-inflammatory, anti-pruritic and vasoconstrictive properties.  Beclomethasone in Kenozole-B Cream works by blocking the production of inflammatory chemicals, like prostaglandins and leukotrienes, which are hormone-like substances involved in the inflammatory process.  Beclomethasone in Kenozole-B Cream also narrows and constricts causes blood vessels that have become dilated (widened) and leaky allowing other inflammatory cells into the skin to escalate the inflammatory response.  This reduces symptoms of inflammation associated with fungal infection.  Kenozole-B Cream also contains ketoconazole, a synthetic broad-spectrum antifungal that is used to treat a variety of fungal infections.  Ketoconazole in Kenozole-B Cream 2% prevents growth of dermatophyte and yeast fungi by inhibiting the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells.  This results in altering the permeability of the fungal cell membrane causing it to become weakened, so that the cell contents to leak out, which kills the fungus, preventing the infection from spreading and relieving symptoms caused by the fungal infection, including pain and inflammation.  When used as a topical antifungal, no detectable ketoconazole enters the blood, reducing risk of systemic side effects. 

What does Kenozole-B Cream contain?

Kenozole-B Cream contains the active ingredients Beclomethasone  dipropionate 0.025% (w/w) an antiinflammatory corticosteroid and ketoconazole 2% (w/w), a broad-spectrum antifungal that are used together to treat fungal infections with inflammation.  It also contains methyl paraben and propyl paraben as preservative.

Treating fungal infections with Kenozole-B Cream

Kenozole-B Cream contains a combination of an antifungal and an anti-inflammatory corticosteroid used together as a topical treatment for fungal infections of the skin and scalp, where there are with inflammatory changes or a hypersensitivity reaction.  Kenozole-B Cream is effective against Tinea, a dermatophyte fungus also known as ringworm that causes fungal infection in different parts of the body including the foot, also known as Athlete's foot (tinea pedis), the body (tinea corporis), the groin (tinea cruris or jock itch), and the scalp (tinea capitis).  Kenozole-B Cream 2% is also used to treat infection by the yeast fungus Malassezia, which causes Pityriasis versicolor, characterised by flaky discoloured patches that appear on the chest and back; also seborrhoeic dermatitis, a form of dermatitis or inflammation of the skin that affects mainly the scalp and face.  Kenozole-B Cream 2% is also effective against infection with  the yeast fungus Candida, which causes cutaneous candidiasis, characterised by itchy red rash on various parts of the body, usually in warm, moist creased areas of skin, like under the arms and in the groin.  Beclomethasone in Kenozole-B Cream works by blocking the production of inflammatory chemicals, like prostaglandins and leukotrienes; it also narrows and constricts causes blood vessels preventing leaking of inflammatory cells into the skin to escalate the inflammatory response. This reduces symptoms of inflammation associated with fungal infection.  Ketoconazole in Kenozole-B Cream 2% prevents growth of dermatophyte and yeast fungi by inhibiting the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells.  This results in altering the permeability of the fungal cell membrane causing it to become weakened, so that the cell contents to leak out, which kills the fungus, preventing the infection from spreading and relieving symptoms caused by the fungal infection, including pain and inflammation. 

What are the side effects of Kenozole-B Cream?

The most commonly reported side effects when using Kenozole-B Cream include burning sensation or irritation at the site of application, such as redness, pain and swelling; oily or dry scalp, mild hair loss, skin atrophy.  Long-term use of Kenozole-B Cream may cause the adrenal glands, which produce endogenous (naturally occurring) corticosteroids, to stop working efficiently and this may slow down the growth rate in children.

When should Kenozole-B Cream not be used?

You should not use Kenozole-B Cream if you:

• are allergic to beclomethasone or ketoconazole or any ingredients in Kenozole-B Cream
• are pregnant or are breastfeeding
• have a viral infection of the skin, tuberculosis, acne rosacea (a chronic skin condition), perioral dermatitis (facial rash around the mouth), fungal skin infections and ulcerative conditions
• have damaged skin

How should Kenozole-B Cream be used?

You should apply a thin film of Kenozole-B Cream to the affected area of skin once daily, gently rubbing into the skin.  You should always wash your hands after applying the medication and make sure you don’t get any in your eyes, nose or mouth.  Kenozole-B Cream is intended for short term use and should not be used for more than 2 weeks.  If there is no improvement in symptoms within 2 weeks, you should follow you doctors recommendations.  

How long should you use Kenozole-B Cream?

Kenozole-B Cream is intended for short term use and should not be used for more than 2 weeks.  If there is no improvement in symptoms within 2 weeks, you should follow you doctors recommendations.  

Missed dose of Kenozole-B Cream

If you miss a dose of Kenozole-B Cream apply it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Kenozole-B Cream be stored?

You should store your Kenozole-B Cream below 25°C in a cool dry place.