Topiramate 25mg Actavis

Topiramate Actavis general information

What is Topiramate Actavis used for?

Topiramate Actavis tablets 25mg are used to treat epilepsy in adults and children to control seizures, which happen when there is abnormal electrical activity in the brain.  Topiramate Actavis tablets 25mg are used as monotherapy (on its own) for adults and children (over 2 years) who have just been diagnosed with idiopathic epilepsy (of unknown cause) and who have either generalised tonic-clonic seizures, seizures affecting the whole brain (formerly known as grand mal seizures), which usually last 1-3 minutes; or partial seizures, which affect only part of the brain but can spread to the whole brain and these are called secondarily generalised seizures.  Topiramate Actavis tablets 25mg are also used in addition to another medication for controlling seizures in adults and children (over 2 years of age) in partial onset seizures, generalised tonic-clonic seizures but who have been unable to achieve control of seizures with other medications; also in children for treatment seizures associated with of Lennox-Gastaut syndrome, a form of childhood-onset epilepsy that causes frequent seizures and developmental problems.  Topiramate Actavis 25 is also used for the prevention of migraines in adults who have regular migraines (3 or more per month). 

How does Topiramate Actavis work?

Topiramate Actavis tablets 25mg contain topiramate, an anticonvulsant used to treat epilepsy and control seizures.  Nerve cells throughout the central nervous system communicate by sending out electrical signals, generated by the movement of electrically charged particles in and out of nerve cells, which travel to the all parts of the body via chemical messengers called neurotransmitters.  This usually happens in an orderly fashion to control all our actions and thought processes.  Epileptic seizures are thought to be caused by abnormal electrical activity in the brain, with uncontrolled, rapid and repetitive electrical signals being sent continually to various parts of the body, although the trigger for this abnormality is not known.  Topiramate in Topiramate Actavis tablets 25mg works directly on the brain cells to reduce the rate at which electrical signals are generated, calming the overactive nerve activity, by three different mechanisms.  Conduction of electrical impulses is dependent on the flow of positive sodium ions into and out of the nerve cell through special sodium channels.  Topiramate blocks these sodium channels and therefore reduces the neurone’s ability to send out continuous signals which cause seizures.  Topiramate also has the ability to enhance the activity of gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter that regulates how much neurones can be  excited (stimulated to send out electrical impulses), and inhibits the activity of the excitatory neurotransmitter glutamate, which adds to the calming effect on brain electrical activity.  These three mechanisms are thought to contribute to the anticonvulsant activity of Topiramate Actavis 25, which control seizures in epilepsy, but cannot cure them.

What does Topiramate Actavis contain?

Topiramate Actavis tablets 25mg contain the active ingredient topiramate, which is an anticonvulsant used to treat epilepsy and control seizures.  They also contain mannitol, microcrystalline cellulose, pregelatinised maize starch, magnesium stearate, croscarmellose sodium, and the colouring Opadry II Yellow 85G32312.

Treating epilepsy with Topiramate Actavis

Topiramate Actavis tablets 25mg contain topiramate, an anticonvulsant used to treat epilepsy in adults and children to control tonic-clonic seizures, seizures affecting the whole brain (formerly known as grand mal seizures), and partial seizures, which affect only part of the brain but can spread to the whole brain and are called secondarily generalised seizures.  Epileptic seizures happen when there is abnormal electrical activity in the brain, with uncontrolled, rapid and repetitive electrical signals being sent continually to various parts of the body, although the trigger for this abnormality is not known.  Topiramate in Topiramate Actavis tablets 25mg works directly on the brain to reduce the rate at which electrical signals are generated, by blocking the ability of nerve cells to transmit electrical signals.  This action is thought to contribute to the anticonvulsant activity of Topiramate Actavis tablets 25mg, which prevent the overload of electrical activity in the brain that causes seizures in epilepsy and therefore controls the seizures, but cannot cure epilepsy.

Topiramate Actavis for preventing migraine

Topiramate Actavis tablets 25mg contain topiramate, an anticonvulsant that is used to treat epilepsy to control seizures.  They are also used for the prevention of migraines in adults who have regular migraines (3 or more per month) that interfere with normal daily activities.  Topiramate in Topiramate Actavis tablets 25mg works directly on the brain to reduce the rate at which electrical signals are generated and reducing the transmission of electrical signals by over excitable nerve cells.  This action of Topiramate Actavis tablets 25mg is thought to contribute to the blocking of pain signals, which reduces the occurrence of a migraine headache.  Topiramate Actavis tablets 25mg are not intended to treat a migraine attack but can control the number of migraine attacks if they happen regularly and frequently, to help you manage your daily life.

What are the side effects of Topiramate Actavis?

The most commonly reported side effects when taking Topiramate Actavis 25mg include: unusual tiredness, drowsiness, weakness, dizziness; decrease in appetite or weight loss, slowness of thought processes (bradyphrenia), tingling and numbness of hands and feet (paresthesia); headache; nausea, diarrhoea, constipation; memory impairment; double vision (diplopia); inability to sleep; speech disturbances; anxiety and depression;

When should Topiramate Actavis not be used?

You should not use Topiramate Actavis 25mg if you:

• are allergic to topiramate or any ingredients in Topiramate Actavis
• are pregnant or are breastfeeding
• have or have had kidney stones
• have kidney disease or liver disease or glaucoma
• have a psychiatric disorder
• are taking medication that interact with Topiramate Actavis, including: other epilepsy medicines like phenytoin or carbamazepine; digoxin for heart failure; CNS depressant medicines and alcohol; oral contraceptives; lithium and risperidone (for bipolar disorder and schizophrenia), the diuretic hydrochlorothiazide; metformin, pioglitazone, glibenclamide for diabetes; the anticonvulsant valproic acid
• are taking any medicine which slows your reactions, such as  medicines to help you sleep or relieve pain, antidepressants, tranquillisers or antihistamines which can make you drowsy

What medications interact with Topiramate Actavis?

Several medications interact with Topiramate Actavis 25mg and should either not be taken while you are taking Topiramate Actavis or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction or increases side effects with Topiramate Actavis: any medicine which slows your reactions (CNS depressants), such as medicines to help you sleep or relieve pain, antidepressants, tranquillisers or antihistamines which can make you drowsy and the effects may be worse when combines with Topiramate Actavis; the anticonvulsant valproic acid can cause metabolic disturbances
• Drugs that affect Topiramate Actavis: other epilepsy medicines like phenytoin or carbamazepine; the diuretic hydrochlorothiazide
• Drugs that are affected by Topiramate Actavis; digoxin for heart failure; oral contraceptives; lithium and risperidone (for bipolar disorder and schizophrenia); metformin, pioglitazone, glibenclamide for diabetes

How should Topiramate Actavis be taken?

You should take your Topiramate Actavis 25mg swallowed whole with a glass of water, with or without food, once daily preferably at the end of the day.  Your doctor will probably start you on a low dose and then increase your dose, which may be taken as 2 tablets morning and evening, depending on how well you respond, what you are being treated for and your doctor’s recommendation.  You should take your Topiramate Actavis 25mg continually for as long as recommended by your doctor, which may be for several months or longer and you should not stop taking your tablets, you will probably discontinue treatment gradually.

How long should you take Topiramate Actavis?

You should take your Topiramate Actavis tablets 25mg continually for as long as recommended by your doctor, which may be for several months or longer.

Missed dose of Topiramate Actavis

If you miss a dose of Topiramate Actavis take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Topiramate Actavis be stored?

You should store your Topiramate Actavis below 25°C in a cool dry place.