Motilium M (Domperidone)

Motilium M General Information

What is Motilium M used for?

Motilium M tablets 10mg are used to treat nausea and vomiting and help relieve symptoms like bloating, fullness, heartburn and flatulence that cause discomfort when your digestive system is out of rhythm or you have eaten too much.  Motilium M 10 can also be used to relieve symptoms of nausea caused by some medications, such as anti-cancer drugs and medications used for Parkinson’s disease.  Another use for Motilium M tablets 10mg is to increase breast milk production, as a side effect of its intended use.   

How does Motilium M work?

Motilium M tablets 10mg contains domperidone, a dopamine antagonist that acts as an antiemetic (prevents nausea and vomiting) and as a gastrokinetic (stimulates gastrointestinal mobility).  Nausea and vomiting are triggered when the chemoreceptor trigger zone (CTZ) in the brain is stimulated and this causes nerve impulses to be sent to area postrema or vomiting centre of the brain, to induce the vomiting reflex.  The CTZ can be activated by two mechanisms; either indirectly by transmission of nerve impulses sent to the brain from the stomach when it has been irritated, or directly by chemicals or drugs that are circulating in the blood and stimulate receptors in the brain.  Motilium M tablets 10mg work by blocking the action of the chemical messenger dopamine and this stops the transmission of messages from the irritated or upset stomach to the brain, preventing the brain triggering the vomiting response.  Motilium M 10 also blocks the same chemical messengers in the upper digestive system.  This relieves dysmobility, which is when food processing slows down causing uncomfortable symptoms.  Motilium M tablets 10mg restores the natural rhythm of muscle contraction and relaxation in the stomach, which helps push food through the digestive system and prevents vomiting.    

What does Motilium M contain?

Motilium M tablets contain the active ingredient domperidone maleate10mg, an antiemetic used to relieve symptoms of nausea and queasiness.  

Treating nausea and vomiting with Motilium M

Motilium M tablets 10mg contain domperidone, a dopamine antagonist that is used as an antiemetic (prevents nausea and vomiting), to treat nausea and vomiting caused by a variety of conditions, including, gastrointestinal disorders or medication such as anti-cancer drugs.  Domperidone in Motilium M 10 works by blocking the action of the chemical messenger dopamine in the brain and in the upper intestine, and this prevents vomiting and restores the natural rhythm of the digestive system.  The action of Motilium M tablets 10mg helps relieve symptoms of digestive problems including bloating, fullness, heartburn, regurgitation of bile, abdominal pain and flatulence, which can happen when the digestive system is out of rhythm and cause discomfort.

How does Motilium M help with breastfeeding?

If you are having trouble producing enough breast milk you can use Motilium M tablets 10mg to help with breastfeeding.  Domperidone in Motilium M tablets 10mg increases blood levels of the hormone prolactin, which stimulates milk production in a new mother’s breast cells.   This is an indirect result of blocking the chemical messenger dopamine, which is also how Motilium M prevents nausea and vomiting.  Domperidone Motilium M 10 does pass from the blood into breast milk, however, it is present in small amounts and there is no indication that it will harm your baby.  Domperidone in Motilium M tablets 10mg has fewer side effects than metoclopramide, which is another medication used for stomach problems that also stimulates milk production.

Motilium M for increasing breast milk production

Motilium M tablets 10mg can be used to increase your breast milk production as it has been found to increase blood levels of the hormone prolactin, which stimulates milk production in a new mother’s breast cells.  This is an indirect result of blocking the chemical messenger dopamine, which is also how Motilium M prevents nausea and vomiting.  Domperidone in Motilium M tablets 10mg does pass from the blood into breast milk, however, it is present in small amounts and there is no indication that it will harm your baby.  Domperidone in Motilium M tablets 10mg has fewer side effects than metoclopramide, which is another medication used for stomach problems that also stimulates milk production.

What are the side effects of Motilium M?

The most commonly reported side effects when taking Motilium M tablets 10mg include headache, abdominal cramps and dry mouth.  Because Motilium M does not cross the blood brain barrier it does not cause what are known as extrapyramidal side effects, like convulsion and involuntary muscle actions that can be associated with some dopamine blocking medications.  However, for the same reason Motilium M can increase the production of the hormone prolactin, which stimulates breast milk secretion, and this can cause breast enlargement (gynaecomastia) and temporary stoppage of periods (amenorrhoea).  These side effects will stop as soon as you stop taking Motilium M.

When should Motilium M not be used?

You should not use Motilium M tablets 10mg if you:

• have a known hypersensitivity to domperidone or any of the other components
• have an intolerance to lactose, a lactose malabsorption or a genetic disorder leading to accumulation of galactose in the blood (galactosaemia), as lactose is used to coat the tablets
• have a condition where increasing gut motility could be harmful, such as gastrointestinal haemorrhage, mechanical obstruction or a perforation
• have a kidney or liver disease
• have a pituitary tumour that causes over-production of prolactin (prolactinoma)
• are taking another medication that may interact with Motilium M and prevent one or both drugs working effectively, such as the antifungals ketoconazole, fluconazole or voriconazole, antibiotics containing erythromycin, clarithromycin or telithromycin; amiodarone for rapid heartbeat.  

How should Motilium M be taken?

You should take Motilium M tablets 10mg swallowed whole with a glass of water 15 to 30 minutes before meals. If you are over 16, you can take a tablet three times a day and at bedtime, if necessary.
To increase breastmilk the usual dosage recommended by lactation consultants is up to TWO tablets FOUR times a day.
The dose you take and for how long depends on what you are being treated for and your doctor’s recommendation.

How long should you take Motilium M?

You should continue to take Motilium M tablets 10mg for as long as recommended by your doctor, however, it is not intended for long-term use and you should not continue to take it for more than two weeks, unless recommended by your doctor.

Missed dose of Motilium M

If you miss a dose of Motilium M 10, take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Motilium M be stored?

Store Motilium M tablets 10mg at room temperature and keep away from direct sunlight.  

Where can you buy Motillium?

Motillium (correctly spelt Motilium M) is a common misspelling of the antiemetic medication which is used to treat nausea and vomiting and help relieve symptoms of bloating and fullness that cause discomfort when your digestive system is out of rhythm.  Motilium M 10 can also be used to relieve symptoms of nausea caused by some medications, such as anti-cancer drugs.  Another use for Motilium M is to increase breast milk production, as a side effect of its intended use.  You can buy Motillium (correctly spelt Motilium M) online at Inhousepharmacy.com.