Resolor (Prucalopride 2mg) Tablets

Resolor general information

What is Resolor used for?

Resolor tablets 2mg are used to treat severe chronic constipation when other laxative medications do not provide relief.  Constipation is usually defined as having less than three bowel movements per week and chronic constipation is when infrequent bowel movement, which is usually accompanied by difficulty in passing stools, continues for several weeks or longer.  Primary constipation often has no underlying cause but is usually due to a basic problem with the function of the colon and the defaecation process and with reduced gastrointestinal motility.  Resolor tablets 2mg are not used to treat secondary constipation which can be due to a bowel obstruction, bowel cancer, spinal cord injury, neurological disorders like multiple sclerosis or Parkinson’s disease, hormonal disorders like diabetes or underactive thyroid (hypothyroidism), and to some medications particularly opiates like morphine and codeine.  Resolor tablets 2mg restore gastrointestinal motility and relieve the discomfort of chronic constipation. 

How does Resolor work?

Resolor tablets 2mg contain prucalopride, a dihydrobenzofurancarboxamide with gastrointestinal prokinetic or enterokinetic activities that is used to treat chronic constipation.  Prucalopride in Resolor tablets 2mg is a selective, high affinity serotonin (5-HT4) receptor agonist and works by binding to the 5-HT4 receptor on the intestinal wall.  Intestinal peristalsis (waves of contraction and relaxation that propels food) is regulated primarily by the neurotransmitter serotonin, due to serotonin mediated release of other neurotransmitters that stimulate (acetylycholine) or inhibit muscular contraction of the intestine, which maintains peristaltic movement of food.  Prucalopride in Resolor tablets 2mg increases the frequency and strength of the muscular contractions of the colon, which stimulates the passage of compacted faeces and restores normal bowel movements. 

What does Resolor contain?

Resolor tablets 2mg contain the active ingredient prucalopride, a serotonin (5-HT4) receptor agonist with gastrointestinal prokinetic activity that is used to treat chronic constipation.

Treating constipation with Resolor

Resolor tablets 2mg contain prucalopride, a serotonin (5-HT4) receptor agonist with gastrointestinal prokinetic activity that is used to treat chronic constipation when other laxative medications do not provide relief, but are not used to treat secondary constipation due to a disorder, obstruction, spinal injury or medication.  Constipation is usually defined as having less than three bowel movements per week and chronic constipation is when infrequent bowel movement, which is usually accompanied by difficulty in passing stools, continues for several weeks or longer, often with no underlying cause.  Chronic constipation is usually due to reduced gastrointestinal motility or peristalsis (waves of contraction and relaxation that propels food), which is regulated primarily by the neurotransmitter serotonin.  Prucalopride in Resolor tablets 2mg works by binding to the 5-HT4 receptor on the intestinal wall, which increases the frequency and strength of the muscular contractions of the colon, and stimulates the passage of compacted faeces and restores normal bowel movements.  Resolor tablets 2mg restore gastrointestinal motility and relieve the discomfort of chronic constipation. 

What are the side effects of Resolor?

The most commonly reported side effects when taking Resolor tablets 2mg include nausea, diarrhoea, abdominal pain, vomiting, dyspepsia, headache, dizziness, fatigue decreased appetite.

When should Resolor not be used?

You should not use Resolor tablets 2mg if you:

• are allergic to prucalopride or any ingredients in Resolor
• are pregnant or are breastfeeding
• have liver or kidney disease
• have intestinal perforation or obstruction
• have active severe inflammatory intestinal disease, such as Crohn’s disease ulcerative colitis
• have arrhythmia or cardiovascular disease
• are taking medicines that interact with Resolor including the antibiotic erythromycin, the antifungal ketoconazole, atropine-like substances, medicines known to cause irregular heart beat or other heart problems

What medications interact with Resolor?

Several medications interact with Resolor tablets 2mg and should either not be taken while you are taking Resolor or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction with Resolor: medicines known to cause irregular heart beat or other heart problems
• Drugs that affect Resolor: the antifungal ketoconazole, atropine-like substances
• Drugs that are affected by Resolor: the antibiotic erythromycin

How should Resolor be taken?

You should take your Resolor tablets 2mg swallowed whole with a glass of water, once daily with or without food, at the same time each day.  You should continue to take your Resolor tablets 2mg for as long as recommended by your doctor, usually for at least 4 weeks. 

How long should you take Resolor?

You should continue to take your Resolor tablets 2mg for as long as recommended by your doctor, usually for at least 4 weeks. 

Missed dose of Resolor

If you miss a dose of Resolor tablets 2mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Resolor be stored?

You should store your Resolor tablets 2mg below 25°C in a cool dry place and protect from moisture.