Fenolip-145 (Fenofibrate)

Fenolip-145 general information

What is Fenolip-145 used for?

Fenolip-145 tablets are used to treat dyslipidaemia, which is an imbalance in blood lipids, usually too much cholesterol or triglyceride. Fenolip-145 lowers high levels of cholesterol (hypercholesterolaemia) and triglycerides, which are other fats in the blood (hypertriglyceridaemia) to reduce health risks associated with coronary heart disease (CHD), including heart attack and angina that can be caused by high cholesterol. Fenolip-145 is also to treat dyslipidaemias caused by other conditions such as diabetes or thyroid disease. Fenolip tablets 145mg are used to treat people with high cholesterol or triglycerides when diet and exercise alone does not adequately lower blood lipid levels. There are usually no symptoms when you have high cholesterol, which may be due to lifestyle (high-fat diet and lack of exercise) or can be inherited.

How does Fenolip-145 work?

Fenolip-145 tablets contain fenofibrate that belongs to the fibrate group of drugs, is a derivative of fibric acid and is used to reduce levels of blood cholesterol and triglycerides. Cholesterol is needed by the body for many functions such as building cell membranes, producing certain hormones and transporting fat soluble vitamins around the body. However, if there is more cholesterol than the body needs (hypercholesterolaemia), it becomes deposited in the artery walls where it can build up, blocking the arteries (atherosclerosis), and increasing risk of heart disease. Triglycerides are the most common type of body fat stored in fat cells and are a major source of energy, but if you consume more fat than your body needs you will have too much triglyceride in your blood (hypertriglyceridaemia). Fenofibrate in Fenolip-145 exerts its lipid-lowering effects by activation of Peroxisome Proliferator Activated Receptor type alpha (PPARα). This is a receptor in the nucleus of cells that regulates the synthesis and activation of lipoprotein lipase. This enzyme breaks down blood lipids including cholesterol and triglycerides, a process called lipolysis, and lowers levels of low density lipoprotein (LDL) or “bad” cholesterol that can cause arteries to become hardened and blocked. Apoproteins are proteins that transport lipids around the body and fenofibrate in Fenolip-145 also reduces the production of apoprotein CIII, which inhibits lipoprotein lipase and increases the amount of LDL and triglycerides in the blood. It also increases the synthesis of apoproteins AI and AII, which increases levels of high density lipoprotein (HDL) or “good” cholesterol that helps unblock hardened arteries. The overall effect of Fenolip-145 tablets is to lower triglycerides, total cholesterol, and LDL (bad) cholesterol, and increase HDL (good) cholesterol, which helps prevent atherosclerosis and reduces the risk of heart disease.

What does Fenolip-145 contain?

Fenolip-145 tablets contains the active ingredient fenofibrate (145mg) that is used to lower blood levels of cholesterol and triglycerides to reduce risk of coronary heart disease.

Treating dyslipidaemia with Fenolip-145

Fenolip-145 tablets contains fenofibrate that is used to treat dyslipidaemia, which is an imbalance in blood lipids, to reduce risk of coronary heart disease (CHD), including heart attack and angina that can be caused by high cholesterol. Cholesterol is needed by the body for many functions such as building cell membranes, producing certain hormones and transporting fat soluble vitamins around the body. However, if there is more cholesterol than the body needs (hypercholesterolaemia), it becomes deposited in the artery walls where it can build up, blocking the arteries (atherosclerosis), and increasing risk of heart disease. Triglycerides are the most common type of body fat stored in fat cells and are a major source of energy, but if you consume more fat than your body needs you will have too much triglyceride in your blood (hypertriglyceridaemia). Fenofibrate in Fenolip-145 exerts its lipid-lowering effects by activating the enzyme lipoprotein lipase which increases the breakdown of triglycerides and low density lipoprotein (LDL) or “bad” cholesterol that can cause arteries to become hardened and blocked; it also increases the amount of the apoprotein that transports high density lipoprotein (HDL) or “good” cholesterol that helps unblock hardened arteries and increases levels of HDL in the blood. The overall effect of Fenolip-145 tablets is to lower triglycerides, total cholesterol, and LDL (bad) cholesterol, and increase HDL (good) cholesterol, which helps prevent atherosclerosis and reduces the risk of heart disease.

What are the side effects of Fenolip-145?

The most commonly reported side effects when taking Fenolip-145 include: gastrointestinal disturbances (abdominal pain, nausea, vomiting, diarrhoea, and flatulence), pancreatitis (inflammation of the pancreas leading to abdominal pain), abnormal liver function tests, gall stones (cholelithiasis), skin rash and itching (pruritus) urticaria (hives), photosensitivity reactions.

When should Fenolip-145 not be used?

You should not use Fenolip-145 if you:

• are allergic to fenofibrate or any ingredients in Fenolip-145
• are pregnant or are breastfeeding
• have kidney, liver disease or gallbladder disease
• have pancreatitis
• are taking medicines that interact with Fenolip-145, including: anticoagulants like warfarin, other medications for high cholesterol like statins, the immunosuppressant cyclosporin

How should Fenolip-145 be taken?

You should take your Fenolip-145 tablets with a glass of water, once daily with or without food. You should continue to take your Fenolip-145 for as long as recommended by your doctor.

How long should you take Fenolip-145?

You should continue to take your Fenolip-145 for as long as recommended by your doctor.

Missed dose of Fenolip-145

If you miss a dose of Fenolip-145 take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Fenolip-145 be stored?

You should store your Fenolip-145 below 25°C in a cool dry place.