TMP 300 (Trimethoprim) 300mg

TMP general information

What is TMP used for?

TMP tablets 300mg (also known as Proloprim and Trimpex) are used to treat acute urinary tract infections, such as cystitis, caused by certain bacteria, and for long term prophylaxis (prevention) of recurrent chronic urinary tract infection. They are also used to suppress bacterial infections following sterilisation of the urine. TMP 30 can be used alone as monotherapy or in combination with other antibiotics to treat other infections such as pneumonia.

How does TMP work?

TMP tablets 300mg (also known as Proloprim and Trimpex) contain trimethoprim, a synthetic antibiotic with antibacterial activity against a wide range of bacteria, including Staphylococcus species, Enterobacter species Escherichia coli Klebsiella pneumoniae and Proteus mirabilis. Trimethoprim in TMP 300 blocks bacterial folate biosynthesis, needed for biosynthesis of nucleic acids and proteins, by inhibiting a specific bacterial enzyme called dihydrofolate reductase which blocks the conversion of dihydrofolic acid to tetrahydrofolic acid. This action prevents replication of the bacteria stops the spread of infection.

What does TMP contain?

TMP tablets 300mg contain the active ingredient trimethoprim, a synthetic antibiotic with antibacterial activity against a wide range of bacteria. They also contain lactose, magnesium stearate, povidone, sodium starch glycollate, and purified talc.

Treating bacterial urinary infection with TMP

TMP tablets 300mg (also known as Proloprim and Trimpex) contain trimethoprim, a synthetic antibiotic with antibacterial activity against a wide range of bacteria that cause urinary tract infections, such as cystitis. TMP 300 is used to treat acute urinary tract infections, caused by certain bacteria, and for long term prophylaxis (prevention) of recurrent chronic urinary tract infection. Trimethoprim in TMP 300 blocks bacterial folate biosynthesis, needed for biosynthesis of bacterial nucleic acids and proteins, by inhibiting a specific bacterial enzyme called dihydrofolate reductase, which blocks the conversion of dihydrofolic acid to tetrahydrofolic acid. This action prevents replication of the bacteria stops the spread of infection.

What are the side effects of TMP?

The most commonly reported side effects when taking TMP tablets 300mg include: stomach upset, nausea, vomiting, sore mouth, swollen tongue (glossitis), skin rash, itching.

When should TMP not be used?

You should not use TMP tablets 300mg if you:

• are allergic to trimethoprim or any ingredients in TMP 300
• are pregnant or are breastfeeding, withour discussion with your doctor
• have kidney or liver disease
• have a folate deficiency
• have porphyria, a type of blood disorder
• are taking medicines that interact with TMP: other antifolate drugs like the anticancer drug methotrexate, the anticoagulant warfarin, the anti malarial pyrimethamine, the antiepileptic phenytoin, digoxin for heart failure, procainamide for irregular heart beat, amantadine for Parkinson's disease

How should TMP be taken?

You should take your TMP tablets 300mg with a glass of water with food, to help reduce risk of a stomach upset once daily, preferably before bedtime. The dose you take and for how long should be as recommended by your doctor, which may be a few days or weeks, depending on what you are being treated for. You should continue to take your TMP 300 even if you feel better, until you have completed the prescribed course of treatment.

How long should you take TMP?

You should continue to take your TMP 300mg tablets even if you feel better, until you have completed the prescribed course of treatment, which may be a few days or weeks, depending on what you are being treated for and your doctor’s recommendation.

Missed dose of TMP

If you miss a dose of TMP tablets 300mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should TMP be stored?

You should store your TMP tablets 300mg below 25°C in a cool dry place and protect from light.