Scopoderm TTS

Scopoderm TTS general information

What is Scopoderm TTS used for?

Scopoderm TTS is a transdermal patch used to relieve the symptoms of motion sickness, including nausea, vomiting and vertigo. Scopoderm TTS 1.5 can be used to prevent motion sickness due to all forms of travel including, air, sea, train or car travel and will last for up to 3 days, but should be removed when the journey is over.

How does Scopoderm TTS work?

Scopoderm TTS Patches contain scopolamine (also known as hyoscine) an anticholinergic agent that works by acting as a competitive antagonist at the muscarinic acetylcholine receptors in the central nervous system. Motion sickness is caused by conflicting information being received by the brain from the eyes and the vestibular system of the ear (fluid filled canals in the inner ear) where motion or changes in the body’s position is detected. The messages sent by the ear suggest motion, whereas the messages sent by the eye suggest that the body is still and this conflict causes the brain to interpret that there is an ingested toxin that needs to be cleared from the system, which stimulates the area postrema of the brain (induces vomiting when poisons are detected) to induce the vomiting reflex. Scopolamine in Scopoderm TTS patches blocks the transmission of nerve impulses from the inner ear to the vomiting center in the brain, which prevents transmission of nerve signals to receptors in the stomach, so that the vomiting reflex is not induced. Each patch is formulated for transdermal delivery by releasing scopolamine through the intact skin into the systemic circulation continuously for up to 72 hours.

What does Scopoderm TTS contain?

Scopoderm TTS Patches contain the active ingredient scopolamine (also known as hyoscine), an anticholinergic agent used to treat motion sickness. They also contain: light mineral oil, polyisobutylene (1.200.000) and polyisobutylene (35.000); with a backing film of pigmented MDPE/AL/PET/HS Film (vapour coated aluminised polyester) with outer coating of pigmented medium density polyethylene (MDPE) and a heat sealable inner coating; a release controlling membrane of polypropylene film; and a release liner (discarded before use) of silicone/polyester film.

Treating motion sickness with Scopoderm TTS

Scopoderm TTS Patches contain scopolamine (also known as hyoscine) an anticholinergic agent that is used to relieve the symptoms of motion sickness, including nausea, vomiting and vertigo. Motion sickness is caused by conflicting information being received by the brain from the eyes and the vestibular system of the ear (fluid filled canals in the inner ear) where motion or changes in the body’s position is detected. The messages sent by the ear suggest motion, whereas the messages sent by the eye suggest that the body is still and this conflict stimulates the area postrema of the brain (vomiting centre) to induce the vomiting reflex. Scopolamine in Scopoderm TTS patches blocks the transmission of nerve impulses from the inner ear to the vomiting center in the brain, which prevents transmission of nerve signals to receptors in the stomach, so that the vomiting reflex is not induced. Each patch last up to 3 days and can be used to prevent motion sickness due to all forms of travel including, air, sea train or car travel.

What are the side effects of Scopoderm TTS?

The most commonly reported side effects when taking Scopoderm TTS include: dry mouth, blurred vision, drowsiness, local irritation at the site of application, irritation of the eyelids.

When should Scopoderm TTS not be used?

You should not use Scopoderm TTS if you:

• are allergic to scopolamine or any ingredients in Scopoderm TTS
• are pregnant or are breastfeeding
• have kidney or liver disease
• have glaucoma
• have pyloric stenosis, bladder outflow obstruction or intestinal obstruction
• have epilepsy as they may worsen your condition
• drink alcohol
• are taking medicines that interact with Scopoderm TTS, including, other anticholinergics like belladonna alkaloids, antihistamines, TCA, amantadine for Parkinson’s disease, the antiarrhythmic quinidine, other drugs that act on the CNS like the antipsychotic chlorpromazine or the sedative benzodiazepines diazepam

How should Scopoderm TTS be used?

You should apply your Scopoderm TTS patch to a clean dry hairless area of skin behind the ear, and be careful to avoid any cuts or irritated areas on your skin. For maximum benefit you should apply your Scopoderm TTS patch 5-6 hours before embarking on a journey, to allow the active ingredients to absorb into your circulation. When you have applied your patch wash your hands and avoid contact with the eyes as it can cause irritation. Keep your Scopoderm TTS patch as dry as possible and remove after 3 days. If your journey is longer than 3 days, use a fresh patch. Also if your patch becomes detached use a fresh patch. When you have completed your journey, remove the patch and wash the area of skin where the patch was applied.

How long should you use Scopoderm TTS?

Scopoderm TTS patch will last for 3 days. If your journey is longer than 3 days, use a fresh patch.,

How should Scopoderm TTS be stored?

You should store your Scopoderm TTS below 25°C in a cool dry place but do not freeze.