Venlor XR 37.5mg

Venlor XR general information

What is Venlor XR used for?

Venlor XR capsules 37.5mg are used to treat major depression and symptoms of depressive illness, including anxiety, loss of interest in usual activities, disturbed sleep, change in appetite, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide. Venlor XR capsules 37.5mg are also used to treat other mood disorders that affect daily activities and relationships with others including, social anxiety disorder (Social Phobia), panic disorder (panic attacks) and generalised anxiety disorder.

How does Venlor XR work?

Venlor XR capsules 37.5mg contain venlafaxine which is an antidepressant belonging to the class of drugs known as Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs) but is structurally and chemically different to other antidepressants. Venlafaxine in Venlor XR capsules 37.5mg acts in the brain to correct the chemical imbalance caused by a lack of certain neurotransmitters (brain chemical that allows nerve cells to communicate) that is thought to be one of the major causes of depression and other mood disorders, particularly a lack of serotonin, which controls many body activities, including regulating mood. Venlafaxine is a potent inhibitor of the reuptake of serotonin and noradrenaline, and also weakly inhibits dopamine reuptake, which means that it blocks the re-uptake of serotonin and noradrenaline from the synapse (the gap between nerve cells across which chemical messages are sent from one nerve cell to another). If the re-uptake of serotonin and noradrenaline by the first nerve cell (pre-synaptic) is blocked, this means that there is more neurotransmitter remaining for the receiving nerve cell (post-synaptic), which allows nerve cells to communicate with each other for longer. The action of Venlor XR capsules 37.5mg helps relieve symptoms of depression and other mood disorders by increasing the amount of serotonin and noradrenaline in the brain, which in turn increases stimulation of nerve pathways that control mood. Venlor XR capsules 37.5mg are formulated so that venlafaxine is released slowly from spheroids within the capsule into the digestive system for extended-release of the medication.

What does Venlor XR contain?

Venlor XR capsules 37.5mg contain venlafaxine hydrochloride, an antidepressant belonging to the class of drugs known as Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs) used to treat depression and other mood disorders.

What doses of Venlor XR are available?

Venlor XR capsules are available to buy from Inhouse Pharmacy in 3 different doses: 37.5mg, 75mg and 150mg.

Treating depression with Venlor XR

Venlor XR capsules 37.5mg contain venlafaxine which is an antidepressant belonging to the class of drugs known as Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs), used to treat symptoms of depression, including anxiety, loss of interest in usual activities, disturbed sleep, change in appetite, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating and recurrent thoughts of suicide. One of the major causes of depression is thought to be an imbalance of neurotransmitters (brain chemicals that allows nerve cells to communicate), particularly a lack of serotonin that controls mood. Venlor XR capsules 37.5mg works by specifically blocking the reuptake of serotonin and noradrenaline from the synapse, or gap between nerve cells across which chemical messages are sent to allow nerve cell to communicate with each other. By preventing the reuptake of serotonin and noradrenaline by the first nerve cell (pre-synaptic) there is more neurotransmitter remaining for the receiving nerve cell (post-synaptic), so that nerve cells can communicate with each other for longer which increases stimulation of nerve pathways that control mood changes, relieving symptoms of depression.

Treating anxiety with Venlor XR

Venlor XR capsules 37.5mg contain venlafaxine which is an antidepressant belonging to the class of drugs known as Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs), used to treat several anxiety-related conditions, including social anxiety disorder (Social Phobia), panic disorder (panic attacks) and generalised anxiety disorder, where excessive anxiety causes constant and uncontrollable feelings of worry and distress, making you feel irritable, and have difficulty thinking and sleeping. Other common symptoms associated with anxiety may include muscle tension, dry mouth, a lump in the throat, cold clammy hands, diarrhoea and nausea. One of the major causes of anxiety is thought to be an imbalance of neurotransmitters (brain chemicals that allows nerve cells to communicate), particularly a lack of serotonin that controls mood and noradrenaline that is related to drive and motivation. If there is a lack of serotonin, the brain cells involved in nerve pathways that control mood changes generate feelings of anxiety and panic instead of well-being, which is associated with high levels of serotonin. Venlor XR capsules 37.5mg works by specifically blocking the reuptake of serotonin and noradrenaline from the synapse, or gap between nerve cells across which chemical messages are sent to allow nerve cell to communicate with each other. By preventing the reuptake of serotonin and noradrenaline by the first nerve cell (pre-synaptic) there is more neurotransmitter remaining for the receiving nerve cell (post-synaptic), so that nerve cells can communicate with each other for longer which increases stimulation of nerve pathways that control mood changes, relieving symptoms of anxiety.

What are the side effects of Venlor XR?

The more common side effects reported when taking Venlor XR capsules 37.5mg are generally mild and transient and usually disappear with continued treatment. They include: decreased or loss of appetite, dry mouth, diarrhoea, nausea, sleeplessness, fatigue, drowsiness, increased sweating, vasodilation (hot flashes), hypertension (increase in blood pressure), sexual problems.

When should Venlor XR not be used?

You should not use Venlor XR if you:

• are allergic to venlafaxine or any of the ingredients in Venlor XR capsules 37.5mg
• are pregnant, plan to become pregnant or are breastfeeding
• have liver disease, a recent history of myocardial infarction or unstable heart disease
• taking any monoamine oxidase inhibitor medications (such as phenelzine and tranylcypromine) as these can cause serious reactions if taken with Venlor XR or within 14 days
• taking other medication that interacts with Venlor XR, including, monoamine oxidase inhibitors (MAOIs) for depression, other antidepressants, the analgesic tramadol, tryptophan, or phentermine (weight-reducing medicines), migraine medicines like sumatriptan, the antipsychotic pimozide, herbal remedies containing St. John´s Wort, bupropion, for nicotine dependence, the antifungal ketoconazole, the antibiotic erythromycin, clozapine for schizophrenia
• are taking medication that affects blood clotting as these may increase risk of bleeding if taken with Venlor XR

What medications interact with Venlor XR?

Several medications interact with Venlor XR and should either not be taken while you are taking Venlor XR or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction with Venlor XR: monoamine oxidase inhibitors (MAOIs) for depression, medication that affects blood clotting like warfarin, as these may increase risk of bleeding if taken with Venlor XR
• Drugs that affect Venlor XR: tramadol (analgesic), sibutramine (weight-reducing medicines), medicines used to treat migraine, e.g. sumatriptan, St John's wort, a herbal remedy used to treat mood disorders, cimetidine for reflux and ulcers, antifungal ketoconazole, antibiotic erythromycin
• Drugs that are affected by Venlor XR: the antidepressants lithium and Imipramine, clozapine for schizophrenia, the anticoagulant warfarin

How should Venlor XR be taken?

You should take your Venlor XR capsules 37.5mg with a glass of water, swallowed whole with food once a day, at the same time each day, for several weeks or months, depending on your condition and your doctor’s recommendations. Your doctor may increase your dose, depending on what you are being treated for.

How long should you take Venlor XR?

You should take your Venlor XR capsules 37.5mg regularly for as long as recommended by your doctor, usually for several weeks or months and you should continue your medication even if you feel well.

Missed dose of Venlor XR

If you miss a dose of Venlor XR capsules 375mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Venlor XR be stored?

You should keep your Venlor XR capsules 37.5mg in their blister packs until use and store below 30°C in a cool dry place.