Strone-50 Injection IM (Progesterone) 10 Ampoules/Pack

Strone-50 general information

What is Strone-50 used for?

Strone-50 injection is used to prevent miscarriage and help an early pregnancy to continue where there have been previous repeated unexplained miscarriages; or where the body has not produced enough progesterone to maintain the pregnancy due to a luteal phase defect. Strone-50 injection is also used to help with certain infertility treatments, including In-Vitro Ferilisation (IVF) or Gamete Intra-Fallopian Transfer (GIFT). In selected cases Strone-50 injection helps increase the chances that the fertilised egg will successfully implant into the endometrium. Another use for Strone-50 injection is to treat dysfunctional uterine bleeding, which is abnormal bleeding and includes heavy bleeding (menorrhagia), irregular bleeding, spotting mid-cycle, post-menopausal bleeding or no bleeding (amenorrhea). Uterine bleeding disorders are usually due to a hormonal imbalance between oestrogen and progesterone and Strone-50 injection is used to help restore this balance.

How does Strone-50 work?

Strone-50 injection contains progesterone, a hormone that is involved in regulating the normal menstrual cycle and is naturally produced by the ovaries during the second phase or luteal phase of the cycle. It acts on the endometrium (lining of the uterus) converting the proliferating phase to the secretory phase to prepare the endometrium for a pregnancy. This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, if conception occurs; if not, levels of oestrogen and progesterone fall and the endometrium is shed (menstruation). Progesterone is produced by the corpus luteum in the ovary for the first few weeks of pregnancy (8-12 weeks) and once the fertilised egg has successfully implanted into the endometrium, progesterone is produced by the developing placenta to continue the pregnancy. Strone-50 injection helps maintain progesterone at levels that are sufficient for implantation to occur and for a pregnancy to continue to reduce the risk of a miscarriage. Strone-50 injection also helps maintain sufficient levels of progesterone for increasing the success of assisted fertility treatment for infertility; also progesterone in Strone-50 injection helps restore the balance between oestrogen and progesterone to correct uterine bleeding disorders.

What does Strone-50 contain?

Strone-50 injection contains the active ingredient progesterone a naturally produced hormone involved in the normal menstrual cycle and in maintaining a pregnancy. Each ampoule contains 50mg progesterone per 1mL in a medium chain triglyceride oil base with benzyl alcohol as preservative.

Treating threatened miscarriage with Strone-50

Strone-50 injection contains progesterone that is used to help prevent an early miscarriage and help the pregnancy to continue where there have been previous repeated unexplained miscarriages or miscarriage due to insufficient progesterone production to maintain the pregnancy due to a luteal phase defect. Progesterone is a natural hormone produced by the ovaries during the luteal phase of the menstrual cycle and acts on the endometrium (lining of the uterus) converting the proliferating phase to the secretory phase. This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, following conception. Progesterone is produced by the corpus luteum in the ovary for the first few weeks of pregnancy (8-12 weeks) and once the fertilised egg has successfully implanted into the endometrium, progesterone is produced by the developing placenta to continue the pregnancy. Strone-50 injection helps maintain progesterone levels needed for implantation and to continue the pregnancy to reduce the risk of a miscarriage.

Strone-50 for assisted fertility treatment

Strone-50 injection contains progesterone that is used to help increase the success of assisted fertility treatment for infertility. These include In-Vitro Ferilisation (IVF) or Gamete Intra-Fallopian Transfer (GIFT). Progesterone is a natural hormone produced by the ovaries during the luteal phase of the menstrual cycle and acts on the endometrium (lining of the uterus) converting the proliferating phase to the secretory phase. This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, following conception. Progesterone is produced by the corpus luteum in the ovary for the first few weeks of pregnancy (8-12 weeks) and then once the fertilised egg has successfully implanted into the endometrium, progesterone is produced by the developing placenta to continue the pregnancy. In selected cases Strone-50 injection helps increase the chances that the fertilised egg will successfully implant into the endometrium so that the pregnancy will continue.

Strone-50 for uterine bleeding disorders

Strone-50 injection contains progesterone that is used to treat dysfunctional uterine bleeding, which is abnormal bleeding and includes heavy bleeding (menorrhagia), irregular bleeding, spotting mid-cycle, post-menopausal bleeding or no bleeding (amenorrhea). Progesterone is a hormone involved in regulating the normal menstrual cycle and is naturally produced by the ovaries during the second or luteal phase of the cycle. It acts on the endometrium (lining of the uterus) converting the proliferating phase to the secretory phase to prepare the endometrium for a pregnancy. This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, if conception occurs; if not, levels of oestrogen and progesterone fall and the endometrium is shed (menstruation). Uterine bleeding disorders are usually due to a hormonal imbalance between oestrogen and progesterone and Strone-50 injection is used to help restore this balance.

What are the side effects of Strone-50?

The most commonly reported side effects when taking Strone-50 include: menstrual changes (breakthrough bleeding, spotting, or missed periods) oedema (fluid retention), weight gain or loss dizziness, drowsiness, fever, headache, nausea, somnolence (sleepiness), skin irritation at the site of injection, breast changes. More severe side effects include jaundice.

When should Strone-50 not be used?

You should not use Strone-50 if you:

• are allergic to progesterone or other progestins or any ingredients in Strone-50
• have ever had an incomplete or missed abortion/miscarriage
• have a past or family history of carcinoma of the breast, endometrial carcinoma
• a history of thrombosis (blood clots) or stroke
• abnormal genital bleeding of unknown cause
• have liver disease
• are taking medicines that interact with Strone-50, including bromocriptine (for menstrual problems), the immunosuppressant cyclosporine.

How should Strone-50 be used?

You will be given Strone-50 by intra-muscular injection into the buttock, by your nurse or doctor. The dose you are given and how frequently will depend on what you are being treated for and your doctor’s recommendation. For a threatened miscarriage you will be given one injection immediately, followed by daily injections for 7-10 days. To prevent a miscarriage or to assist with infertility treatment you will be given an injection usually twice weekly from around day 9 up to 12-14 weeks of pregnancy. For uterine bleeding disorders, you will be given an injection daily for 5-10 days until around two days before your period is due.

How long should you take Strone-50?

The dose you are given and how frequently will depend on what you are being treated for and your doctor’s recommendation.

Missed dose of Strone-50

If you have missed a dose of Strone-50 contact your nurse or doctor as soon as you remember.

How should Strone-50 be stored?

You should store your Strone-50 below 25°C in a cool dry place and protect from light.