Dipentum (Olsalazine 500mg) Tablets

Dipentum tablets 500mg are used to treat inflammatory bowel diseases (IBD), which are chronic inflammatory conditions of the digestive tract, with alternating periods of relapse and remission. Ulcerative colitis is an IBD that involves inflammation of the inner lining of the colon and rectum. Dipentum tablets 500mg are used to relieve symptoms of acute ulcerative colitis, such as ulcers and open sores, which cause abdominal pain, cramping and rectal bleeding. They also help maintain remission from symptoms and prevent flare-ups of the disease. Dipentum tablets 500mg can be used alone or in combination with steroids, which are also anti-inflammatory medications.

Dipentum tablets 500mg contain olsalazine, an anti-inflammatory that inhibits the production, by the walls of the large intestine, of several chemicals that are known to cause inflammation. Olsalazine in Dipentum tablets 500mg is a derivative of salicylic acid and is inactive until it reaches the colon, where it is converted to its active form mesalazine or 5-amino-salicylic acid by the action of a specific colonic bacterial enzyme. Mesalazine is thought to block the action of the enzymes cyclo-oxygenase (COX), which produces prostaglandins, and lipoxygenase, which produces leukotrienes. It also inhibits the migration of inflammatory cells like macrophages into intestine wall and acts as an antioxidant, protecting the walls of the intestine from cell damage. Dipentum tablets 500mg act at the site of inflammation in the colon to relieve symptoms of ulcerative colitis.

Dipentum tablets 500mg contain the active ingredient olsalazine an anti-inflammatory used to treat the inflammatory bowel disease ulcerative colitis. They also contain the inactive ingredients: colloidal silicon dioxide, crospovidone, magnesium stearate and povidone.

Dipentum tablets 500mg contain olsalazine, an anti-inflammatory that is used to treat the inflammatory bowel disease ulcerative colitis, which is a chronic inflammatory condition of the large intestine, known as the bowel or colon, with alternating periods of relapse and remission. Olsalazine in Dipentum tablets 500mg is a derivative of salicylic acid and is inactive until it reaches the colon, where it is converted to its active form mesalazine or 5-amino-salicylic acid by the action of a specific colonic bacterial enzyme. Mesalazine is thought to inhibit the production, by the walls of the large intestine, of several chemicals that are known to cause inflammation including prostaglandins and leukotrienes. It also inhibits the migration of inflammatory cells like macrophages into intestine wall and acts as an antioxidant, protecting the walls of the intestine from cell damage. Dipentum tablets 500mg help relieve symptoms of acute ulcerative colitis, such as ulcers and open sores, which cause abdominal pain, cramping and rectal bleeding. They also help maintain remission from symptoms and prevent flare-ups of the disease.

The most commonly reported side effects when taking Dipentum tablets 500mg include, nausea, diarrhoea, abdominal pain, fever, headache, rash, joint pain.

You should not use Dipentum tablets 500mg if you:

• are allergic to olsalazine or any ingredients in Dipentum
• have any sensitivity to salicylates
• are pregnant or are breastfeeding, without discussion with your doctor
• have kidney disease
• have recently had a varicella vaccine for chicken pox (within 6 weeks)
• have a bleeding disorder, peptic ulcer or erosive gastritis
• are taking medicines that interact with Dipentum including, the anticoagulant warfarin or heparin, digoxin for heart failure, the anti-cancer drugs mercaptopurine and thioguanine

Several medications interact with Dipentum tablets 500mg and should either not be taken while you are taking Dipentum or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction with Dipentum: varicella vaccine
• Drugs that are affected by Dipentum: the anticoagulant warfarin or heparin, digoxin for heart failure, the anti-cancer drugs mercaptopurine and thioguanine

You should take your Dipentum tablets 500mg swallowed whole soon after food daily at the same time each day. The dose you take and how often depends on your doctor’s recommendation and how well you respond to treatment. The usual dose is one tablet taken twice daily. You should continue take your Dipentum tablets 500mg for as long as your doctor recommends, which may be for an extended time.

You should continue take your Dipentum tablets 500mg for as long as your doctor recommends, which may be for long periods.

If you miss a dose of Dipentum tablets 500mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

You should store your Dipentum tablets 500mg below 25°C in a cool dry place, well out of reach of children.